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KMID : 0881720120270020188
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Journal of Food Hygiene and Safety
2012 Volume.27 No. 2 p.188 ~ p.193
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Acute Oral Toxicity and Skin Irritation Studies on Natural Dyes Extracted from Chrysanthemum
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Kwon Jung-Ki
An In-Jung
Lee Jin-Seok
Kim Hae-Ri
Jung Ji-Youn
Park Ha-Seung
Kim Dong-Chan
Choi Byung-Jun
Lee Kyu-Min
Park Yong-Jin
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Abstract
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This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was “0” in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score “0” of primary irritation index.
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KEYWORD
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Chrysanthemum, natural dye, acute oral toxicity, skin irritation
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